Tensions run high as Cath, Rob, Ameer and Rhian prepare for their first official day as doctors. Rob is asked to treat the self-proclaimed King of Wales. Fighting bureaucracy, Rob succeeds in getting through to the psychiatric ward, but there are surprising consequences. The usually calm and confident Ameer is thrown when he realises he’s the first doctor to an emergency. His time to step-up comes sooner than he could possibly hope.

Fellow junior doctor, Simon, is heartbroken when Darth, the hospital pathologist, is forced into retirement. Simon’s passion for pathology was kindled when he was exposed to a box set of Quince ME at a young age. Beneath his quirky exterior lies an honest, straight-talking man and he soon becomes a loyal and true friend to the gang.

For Ameer, patients are nothing like the diagrams he’s so used to in the medical textbooks. Struggling to communicate with them, he enlists the help of an actor, who tries to style Ameer into being a suave confident doctor. Ameer discovers that no façade can help you in life-and-death situations.

Sick of listening to Cath and her sexual conquests, Rhian begins a quest for a love. With patients’ relatives to hand and her profile up on a dating site, it should be easy, but the possibility of love comes from an unexpected source.